LUPUS BOLHOSO PDF

Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

Author: Vihn Vudozragore
Country: Italy
Language: English (Spanish)
Genre: Health and Food
Published (Last): 19 April 2005
Pages: 245
PDF File Size: 9.79 Mb
ePub File Size: 10.11 Mb
ISBN: 293-1-73382-313-3
Downloads: 9135
Price: Free* [*Free Regsitration Required]
Uploader: Galrajas

J Am Acad Dermatol. Tense bullae overlying an erythematous base on the right axilla. Approved by the Advisory Board and accepted for publication on Bullous eruptions are rare skin manifestations in SLE.

Bullous systemic lupus erythematosus in a year-old child

Comedones and pitting scars were noted on a partially infiltrated plaque on the chin Figure 1. Histology from skin biopsy revealed subepidermal blister filled with fibrin, lymphomononuclear cells and neutrophils, thickening of the basement membrane in the dermal papillae and mild perivascular lymphoplasmacytic infiltrate in the papillary, superficial dermis Figure 4.

Trichoepithelioma of the vulva: They preferentially affect the torso and supraclavicular region but may also affect the mucosae, particularly in the mouth and pharynx. Am J Clin Dermatol. Tetracycline was suggested at the beginning of the treatment and an antinflammatory and immunoregulator agent that has been successful on the treatment of acneiform conditions. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.

  BHASKARA RAO PETROLEUM REFINING PDF

J Am Acad Dermatol ; Overview of common, rare and atypica manifestations of cutaneous lupus erythematosus and histopathological correlates.

Footnotes Conflict of interest: Clinically, BSLE is characterized by a generalized vesiculobullous eruption, non-cicatricial, restricted to photo-exposed areas, or not. Adjuvant therapies must also be used in cases that do not respond to or are intolerant of dapsone; the use of lkpus, antimalarial agents, mycophenolate mofetil and cyclophosphamide has been reported in the literature.

The histological findings are comparable to those on the literature review, like: SLE with blisters is characterized by polycyclic lesions with blisters on the edges. J J Invest Dermatol.

It is an acquired bullous disease caused by anti-type VII collagen antibodies. The classic histological features of lupus erythematosus LEsuch as epidermal atrophy and luups degeneration of the basal cell layer, are absent in BSLE. How to cite this article. Al-Refu K, Goodfield M. A case of discoid lupus erythematosus masquerading as acne. Author information Article notes Copyright and License information Disclaimer.

It is important to remember that in both EBA and BSLE, anti-type VII collagen antibodies are present in the sublamina densa of the basement membrane zone and that both conditions have similar genetic characteristics as they are both associated with the HLA-DR2 antigen. Rio Branco, 39 Camisa C, Sharma HM. The differential diagnosis of comedogenic discoid CLE are: It is caused or triggered by exposure to ultraviolet radiation, cold and drugs and develops gradually.

We present a typical case of bullous systemic lupus erythematosus and emphasize the importance of clinical and histopathological differential diagnosis with dermatitis herpetiformis.

  JA INKWIZYTOR BICZ BOZY PDF

J Am Acad Dermatol. National Center for Biotechnology InformationU. Colchicine is a therapeutic option for neutrophil-mediated bullous diseases.

Treatment of autoimmune blistering diseases.

There was a problem providing the content you requested

Clinical and laboratory abnormalities in this patient confirmed the suspicion of BSLE. Rio Branco, 39 We report a case of BSLE in a year-old child with systemic lupus erythematosus, treated bolhos prednisone and hydroxychloroquine.

Echocardiogram showed a minimal increase in pericardial fluid and chest radiography showed a mild, bilateral pleural effusion. Clinically, BSLE is characterized by a disseminated vesiculobullous skin rash that may or may not be limited to areas exposed to light.

Autoimmune Diseases

Blisters are formed as a result of severe damage to the basal layer and consequent separation of the basement membrane from keratinocytes. The patient remained stable during 1 year of follow-up. Pruritus may or may not be present. Direct immunofluorescence revealed IgG, IgA and fibrin deposits along the basement membrane zone.

Cutaneous Manifestations of Systemic Lupus Erythematosus

Histopathological examination of the sample from the cervical lymph node biopsy revealed reactive lymphoid hyperplasia. Chronic bolhoxo erythematosus presenting as acneiform lesions. The case described here illustrates the typical signs and symptoms of bullous systemic lupus erythematosus and draws attention to the need for clinical and histopathological differential diagnosis with dermatitis herpetiformis.

Journal List An Bras Dermatol v. Int Soc Dermatol ;